“Propofol and dexmedetomidine are sedative agents used in the intensive care unit (ICU) for patients requiring mechanical ventilation along with fentanyl that has both analgesic and
sedative properties. It has also been shown decreasing overall sedation by implementing
daily interruption of sedative infusions decreased duration of MV and ICU length of stay (LOS). However, there is a lack of data regarding patient’s weight that may play an impact on dosing of sedation.”

Yeary, J.,et al (2020). Adjusted vs Total Body Weight-Based Dosing of Sedation and Analgesia Used in the Intensive Care Unit. Hospital Pharmacy, 55(6), 400–404.