What are effective interventions to decrease CLABSIs in the long term acute care population?

This systematic review and meta-analysis examines the impact of quality improvement interventions on central line–associated bloodstream infections in adult intensive care units. Studies were identified through Medline and manual searches (1995–June 2012). The results suggest that quality improvement interventions contribute to the prevention of central line–associated bloodstream infections. Implementation of care bundles and checklists appears to yield stronger risk reductions.

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Prevention of surgical site infections (Updated)

“The morbidity for 2018 in the US was 157,500 for surgical site infections (SSI), with an estimated mortality of 8,205. 11% of all deaths in intensive care units were associated with SSI. It is a burden for the patient with an additional 11 days of hospitalization for each SSI and a burden to the system with an overall cost of $3.2 billion per year.”1

A collection of 50 PubMed citations has been compiled related to prevention of surgical site infections (SSIs). This material is an update to a 2018 post.

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Bore/Catheter Size and Catheter Associated Urinary Tract Infections (CAUTIs)

PICO question: Is there an association between inserting the smallest bore indwelling urinary catheter and a decreased CAUTI (catheter associated urinary tract infection) rate? Nurse was “looking for evidence-based practice, guideline, high level of evidence to support question.”

Here’s how to access a collection of 7 articles in PubMed.
a. Go to the Woodruff Health Sciences Center Library homepage (http://health.library.emory.edu)
b. Click on PubMed.
c. Then copy and paste the following link into your browser:
https://www-ncbi-nlm-nih-gov.proxy.library.emory.edu/sites/myncbi/1HMKnKhQm_d5i/collections/59174578/public/
d. The references will appear in PubMed. Click on a reference and you will see a Find it at Emory on the right side of the page which will provide links to full text within Emory University’s licensed resources. Emory Healthcare staff may send citations of needed articles they are unable to access to Ask a Librarian; a library staff person will request the article(s) from an outside library and email them to the EHC staff person upon arrival

Here’s notes about items in the collection.

Table 3 in the 2017 systematic review by Meddings et al states for catheter size, “The smallest bore catheter possible with consistent good drainage is recommended to avoid black neck and urethral mucosa trauma.” The two items it cites by Godfrey and Gould are in the PubMed collection.

Table 3 in article by Gao et al. states simply, “Choose a urethral catheter of the right size and right material, based on the patient’s age, sex, and urethral condition, among other characteristics” without any citing any evidence.

The entry for Catheter-associated Urinary Tract Infection (CAUTI) in DynaMed states, “consider using smallest bore catheter possible, with good drainage, to minimize bladder neck and urethral trauma unless not appropriate clinically” and cites and annotates the following guidelines by Gould and Lo that are in the PubMed collection.

Centers for Disease Control and Prevention Healthcare Infection Control Practices Advisory Committee (CDC HICPAC) recommendation grading system
• Category IA – strong recommendation supported by high- to moderate-quality evidence suggesting net clinical benefits or harms
• Category IB – strong recommendation supported by low-quality evidence suggesting net clinical benefits or harms or an accepted practice (for example, aseptic technique) supported by low- to very low-quality evidence
• Category IC – strong recommendation required by state or federal regulation
• Category II – weak recommendation supported by any quality evidence suggesting a trade-off between clinical benefits and harms
• No recommendation/unresolved issue – unresolved issue for which there is low- to very low-quality evidence with uncertain trade-offs between benefits and harms
• Reference – CDC HICPAC guideline on prevention of catheter-associated urinary tract infections

Society for Healthcare Epidemiology of America/Infectious Diseases Society of America (SHEA/IDSA) quality of evidence grades
• Grade I – high-quality evidence
o highly confident that true effect lies close to that of estimated size and direction of effect
o wide range of studies with no major limitations, little variation between studies, and summary estimate has a narrow confidence interval
o true effect is likely to be close to estimated size and direction of the effect, but there is a possibility that it is substantially different
• Grade II – moderate-quality evidence
o only a few studies and some have limitations but not major flaws
o some variation between studies, or the confidence interval of the summary estimate is wide
o true effect may be substantially different from estimated size and direction of the effect
• Grade III – low-quality evidence
o when supporting studies have major flaws, important variation between studies, the confidence interval of the summary estimate is very wide
o no rigorous studies, only expert consensus
• Reference – SHEA/IDSA practice recommendations on strategies to prevent catheter-associated urinary tract infections in acute care hospitals

Here are two of the search strings I used. I skimmed the most recent five years and did not include choose articles that studied only pediatric populations.

(CAUTI OR CAUTIs OR CA-UTI OR CA-UTIs OR catheter associated urinary tract infection OR catheter associated urinary tract infections OR catheter-associated urinary tract infection OR catheter-associated urinary tract infections) AND (small OR smaller OR smallest OR large OR larger OR largest OR size OR sizes OR bore OR bores OR caliber OR calibers)

(bundle OR bundles OR multipronged OR 6-c OR 6c OR toolkit OR toolkits) AND (CAUTI OR CAUTIs OR CA-UTI OR CA-UTIs OR catheter associated urinary tract infection OR catheter associated urinary tract infections OR catheter-associated urinary tract infection OR catheter-associated urinary tract infections) AND (lower OR lowers OR lowered OR lowering OR decrease OR decreases OR decreased OR decreasing OR reduce OR reduces OR reduced OR reducing OR reduction OR reductions OR improve OR improves OR improved OR improving OR improvement OR improvements OR better OR best)

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Important message for Emory Decatur Nurses. The links will not work for you. To access these articles contact the Emory Decatur Library:

Emory Decatur Hospital
Jessica Callaway (Jessica.callaway@emoryhealthcare.org)
404.501.1628

Prevention of surgical site infections (SSIs)

A collection of 71 articles in PubMed has been compiled on prevention of surgical site infections (SSIs). It consists of systematic reviews, meta-analyses, and guidelines from various sources, including Cochrane, WHO and CDC. There is a wide variety of topics: sterile technique, patient engagement, coated sutures, operating room traffic, preoperative bathing, physician 360-degree reporting, forced-air warming, dressings, teamwork and collaboration, and much more. Articles on usage of antibiotics are not included.

To read abstracts and access full text (where available), first go to Emory’s instance of PubMed and copy/paste this URL into the same browser window. Use the “Find It @ Emory” button to access an article’s full text.

The Agency for Healthcare Research and Quality (AHRQ) has several reports and information on prevention of SSIs. Here are some items from their website:

Toolkit to Promote Safe Surgery helps identify opportunities to improve care and safety practices and implement evidence-based interventions to prevent SSIs. The toolkit includes two guides, supplemental tools for each guide, and 15 instructional modules within three phases (on-boarding, implementation, sustainability) to support change at the unit level.

Toolkit to Improve Safety in Ambulatory Surgery Centers addresses what can be done to prevent SSIs and other complications.

Proactive Risk Assessment of Surgical Site Infections in Ambulatory Surgery Centers includes a list of patient factors that make them high-risk, such as obesity, but also includes things that staff do that lead to increasing rates of infection, such as “fail to remove watch/jewelry/fake nails.”

Creating a Culture of Safety in the Ambulatory Surgery Environment Implementation Guide states that an anticipated benefit for ASCs participating in the program includes a reduction in SSIs and other surgical complications.

Advances in the Prevention and Control of HAIs includes a chapter entitled “Development and Implementation of a Consensus Algorithm to Optimize Preoperative Antimicrobial Prophylaxis and Decrease Gram-Positive Surgical Site Infections for Cardiac and Orthopedic Procedures.”

AHRQ has an ongoing safety program for improving surgical care and recovery. One outcome of the 5-year project will be creation of a toolkit. Visit their website for information on the project and how to enroll a hospital in the program.

Encouraging patients to ask about hand hygiene

Here is how to access 13 articles on encouraging patients to ask about hand hygiene (AKA the “it’s okay to ask” campaign).
a. Go to the Woodruff Health Sciences Center Library homepage: http://health.library.emory.edu
b. Click on PubMed.
c. Then paste this links into your browser:
https://www.ncbi.nlm.nih.gov/sites/myncbi/1HMKnKhQm_d5i/collections/52594031/public/

Prevention of postoperative sternal wound infections after cardiac surgery

Go to the HSCL webpage: http://health.library.emory.edu/
Click on PubMed.
Copy this link into your browser and hit enter: https://www.ncbi.nlm.nih.gov/sites/myncbi/1HMKnKhQm_d5i/collections/51096605/public/
The list of references will appear in PubMed.
By using these instructions, you will be able to click on a reference and see the Find it at Emory button which will lead to full text if available.

Here is the search technique that was used: postoperative period AND (thoracic surgery OR cardiac surgical procedures) AND infection AND (sternum OR sternal) AND prevention and control

Neutropenia patient education

Search PubMed using terms “neutropenia and patient education”. Limited to most recent 10 years. Searched Joanna Briggs for “neutropenia and education”

Ching LC. Cochrane review summary for cancer nursing: low-bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia. Cancer Nurs. 2013 Nov-Dec;36(6):493.

Møller T1, Moser C2, Adamsen L1, Rugaard G1, Jarden M1, Bøtcher TS, Wiedenbein L, Kjeldsen L. Early warning and prevention of pneumonia in acute leukemia by patient education, spirometry, and positive expiratory pressure: A randomized controlled trial. Am J Hematol. 2016 Mar;91(3):271-6. doi: 10.1002/ajh.24262. Epub 2016 Feb 9.

Leonard, K. (n.d.). A European survey relating to cancer therapy and neutropenic infections: Nurse and patient viewpoints. European Journal of Oncology Nursing, 16(4), 380-386.

Dunbar, A., Tai, E., Nielsen, D., Shropshire, S., & Richardson, L. (n.d.). Preventing infections during cancer treatment: Development of an interactive patient education website. Clinical Journal of Oncology Nursing, 18(4), 426-431.

Coughlan, M., & Healy, C. (n.d.). Nursing care, education and support for patients with neutropenia. Nursing Standard., 22(46), 35-41.

Rigdon, A. (n.d.). Development of patient education for older adults receiving chemotherapy. Clinical Journal of Oncology Nursing, 14(4), 433-441.

Zitella, L., Friese, C., Hauser, J., Gobel, B., Woolery, M., O’Leary, C., & Andrews, F. (2006). Putting evidence into practice: Prevention of infection. Clinical Journal of Oncology Nursing, 10(6), 739-750.

Quality of life tools for adult patients with cancer undergoing chemotherapy: a systematic review.
[Systematic Review Protocols] AN: JBI4581 Year of Publication 2009

Hodgkinson, Brent. Josephs, Kay. Hegney, Desley. Best practice in the management of primary nocturnal enuresis in children: a systematic review. The JBI Library of Systematic Reviews. 8(5):173-254, 2010. [Systematic Reviews]
AN: JBI4937 Year of Publication 2010