ELECTROLYTE IMBALANCES

A review of evidence in DynaMed identified the following:

Hyponatremia, Prognosis Section Large cohort study (N=950,000+ patients having major surgery).  Patients with preoperative hyponatremia had statistically significantly higher rates of 30-day all-cause mortality,perioperative major coronary events,wound infections, and pneumonia as compared to patients with normal sodium levels.  Arch Intern Med 2012 Oct 22;172(19):1474,

Hypokalemia, Complications Section.  A large prospective cohort study of patients undergoing elective coronary artery bypass grafting showed that patients with hypokalemia may have increased odds of having a perioperative arrhythmia and need for CPR.  JAMA 1999 Jun 16;281(23):2203

A PubMed search (“hypocalcemia”[mesh] OR “hypercalcemia”[mesh] OR “hyperkalemia”[mesh] OR “hypokalemia”[mesh] OR “hypophosphatemia”[mesh] OR “hyperphosphatemia”[mesh]) AND (“Surgical Procedures, Operative”[Mesh]) AND (case-control OR cohort study OR retrospective) identified several additional studies which are available in this MyNCBI Collection.

FLUID RESUSCITATION

Consult the book “Clinical Fluid Therapy in the Perioperative Setting”, 2011.  It is available in the EUH Library and cites evidence for fluid therapy in various settings.

In PubMed, this search will include reports of clinical trials that address fluid therapy in perioperative care of cardiac surgery patients:

(“Isotonic Solutions”[Mesh] OR “Fluid Therapy”[Mesh] OR “Ringer’s solution, potassium-free” [Supplementary Concept] OR “Ringer’s lactate” [Supplementary Concept] OR “bicarbonated Ringer’s solution” [Supplementary Concept] OR “Ringer’s solution” [Supplementary Concept] OR “crystalloid solutions” [Supplementary Concept] OR “Plasmalyte A” [Supplementary Concept] OR “Plasmalyte R” [Supplementary Concept] OR hetastarch) AND “Perioperative Care”[Mesh] AND ( “Thoracic Surgery”[Mesh] OR “Cardiac Surgical Procedures”[Mesh] ) Limits: Clinical Trials, Meta-analysis, Systematic Review